Mats Nilsson's lab

Spatially resolved biology

Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues


Journal article


Marco Vicari, R. Mirzazadeh, A. Nilsson, Reza Shariatgorji, Patrik Bjärterot, L. Larsson, Hower Lee, M. Nilsson, Julia Foyer, Markus Ekvall, Paulo Czarnewski, Xiaoqun Zhang, P. Svenningsson, P. Andrén, J. Lundeberg
Nature Biotechnology, vol. 42, 2024, pp. 1046–1050


Semantic Scholar DOI
Cite

Cite

APA   Click to copy
Vicari, M., Mirzazadeh, R., Nilsson, A., Shariatgorji, R., Bjärterot, P., Larsson, L., … Lundeberg, J. (2024). Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues. Nature Biotechnology, 42, 1046–1050. https://doi.org/10.1038/s41587-023-01937-y


Chicago/Turabian   Click to copy
Vicari, Marco, R. Mirzazadeh, A. Nilsson, Reza Shariatgorji, Patrik Bjärterot, L. Larsson, Hower Lee, et al. “Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues.” Nature Biotechnology 42 (2024): 1046–1050.


MLA   Click to copy
Vicari, Marco, et al. “Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues.” Nature Biotechnology, vol. 42, 2024, pp. 1046–50, doi:10.1038/s41587-023-01937-y.


BibTeX   Click to copy

@article{marco2024a,
  title = {Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues},
  year = {2024},
  journal = {Nature Biotechnology},
  pages = {1046–1050},
  volume = {42},
  doi = {10.1038/s41587-023-01937-y},
  author = {Vicari, Marco and Mirzazadeh, R. and Nilsson, A. and Shariatgorji, Reza and Bjärterot, Patrik and Larsson, L. and Lee, Hower and Nilsson, M. and Foyer, Julia and Ekvall, Markus and Czarnewski, Paulo and Zhang, Xiaoqun and Svenningsson, P. and Andrén, P. and Lundeberg, J.}
}

Abstract

We present a spatial omics approach that merges and expands the capabilities of independently performed in situ assays on a single tissue section. Our spatial multimodal analysis combines histology, mass spectrometry imaging, and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular weight metabolites across tissue regions. We demonstrate the potential of our method using murine and human brain samples in the context of dopamine and Parkinson’s disease.